This presentation will focus on the Institute of Medicine’s (IOM’s) recently released report Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis (2013), as well as the American Society of Clinical Oncology’s (ASCO’s) efforts to implement the report’s recommendations. The IOM concluded that cancer care in the United States is in crisis due to a growing demand for care, combined with the complexity of the disease and its treatment, a shrinking workforce, and rising costs. The report presents a conceptual framework for improving the quality of cancer care, encompassing six interconnected components of care: (1) engaged patients, (2) an adequately-staffed, trained, and coordinated workforce, (3) evidence-based cancer care, (4) a learning health care information technology system for cancer, (5) translation of evidence into clinical practice, quality measurement, and performance improvement, and (6) accessible and affordable cancer care. The IOM’s recommendations for action are structured around these six components. Relevant topics covered include supporting patients in making informed medical decisions consistent with their needs, values, and preferences, reducing disparities in patients’ access to high-quality care, and improving the affordability of cancer care through new payment models and the elimination of waste. A number of ongoing activities are implementing aspects of the IOM’s recommendations, including actions by ASCO. ASCO is launching CancerLinQTM, a rapid learning system that will enable oncologists to analyze aggregated, real-world cancer clinical data in real time and weigh the value of various treatment options. It is also participating in the Choosing Wisely® Initiative, a clinician led-effort to identify common, costly procedures that are not supported by evidence and that require careful consideration by patients and their clinicians before use.